Ptch2 mediates the Shh response in Ptch1-/- cells.

doi:10.1242/dev.110056

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Article

Ptch2 mediates the Shh response in Ptch1-/- cells.

Development (Cambridge, England) - 1 Sept 2014

Alfaro Astrid C, Roberts Brock, Kwong Lina, Bijlsma Maarten F, Roelink Henk

Abstract excerpt

The Hedgehog (Hh) signaling response is regulated by the interaction of three key components that include the sonic hedgehog (Shh) ligand, its receptor patched 1 (Ptch1) and the pathway activator smoothened (Smo). Under the prevailing model of Shh pathway activation, the binding of Shh to Ptch1 (the key Shh receptor) results in the release of Ptch1-mediated inhibition of Smo, leading to Smo activation and...

Topics

Animals
Antiporters
Cell Adhesion Molecules
Chemotaxis
Embryo, Mammalian
Embryoid Bodies
Fibroblasts
HEK293 Cells
Hedgehog Proteins
Humans
Immunoglobulin G
Mice
Mutation
Neurons
Patched Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 25085974
DOI: 10.1242/dev.110056
PMCID: PMC4199129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Patched-1 Receptor

Patched-2 Receptor

Protein Binding