Article
A model for PTCH1/Ptch1-associated tumors comprising mutational inactivation and gene silencing.
International journal of oncology - 1 Dec 2005
Uhmann Anja, Ferch Uta, Bauer Regine, Tauber Svantje, Arziman Zeynep, Chen Claudia, Hemmerlein Bernhard, Wojnowski Leszek, Hahn Heidi
Abstract excerpt
Mutations of the Sonic hedgehog (SHH) receptor, Patched1 (PTCH1), have been identified in a variety of tumors. PTCH1 is usually considered to be a tumor suppressor gene. However, one normal allele is retained in many tumors. We investigated the mechanism of tumorigenesis in murine heterozygous Ptch1 knock-out mice. Here we show that Ptch1 transcripts, which are consistently overexpressed in tumors in these mice,...
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