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Article

Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway.

BMC developmental biology - 19 Feb 2008

Koudijs Marco J, den Broeder Marjo J, Groot Evelyn, van Eeden Fredericus Jm

Abstract excerpt

BACKGROUND: Aberrant activation of the Hedgehog (Hh) signaling pathway in different organisms has shown the importance of this family of morphogens during development. Genetic screens in zebrafish have assigned specific roles for Hh in proliferation, differentiation and patterning, but mainly as a result of a loss of its activity. We attempted to fully activate the Hh pathway by removing both receptors for the Hh...

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Identifiers

PMID: 18284698
DOI: 10.1186/1471-213X-8-15
PMCID: PMC2275722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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