Article
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.
Development (Cambridge, England) - 1 Oct 2002
Bai C Brian, Auerbach Wojtek, Lee Joon S, Stephen Daniel, Joyner Alexandra L
Abstract excerpt
The Shh signaling pathway is required in many mammalian tissues for embryonic patterning, cell proliferation and differentiation. In addition, inappropriate activation of the pathway has been implicated in many human tumors. Based on transfection assays and gain-of-function studies in frog and mouse, the transcription factor Gli1 has been proposed to be a major mediator of Shh signaling. To address whether this...
Topics
- Alleles
- Animals
- Embryonic and Fetal Development
- Fetal Death
- Hedgehog Proteins
- Kruppel-Like Transcription Factors
- Membrane Proteins
- Mice
- Mice, Mutant Strains
- Nervous System
- Oncogene Proteins