Article
Patched1 is required in neural crest cells for the prevention of orofacial clefts.
Human molecular genetics - 15 Dec 2013
Metzis Vicki, Courtney Andrew D, Kerr Markus C, Ferguson Charles, Rondón Galeano Maria C, Parton Robert G, Wainwright Brandon J, Wicking Carol
Abstract excerpt
Defects such as cleft lip with or without cleft palate (CL/P) are among the most common craniofacial birth defects in humans. In many cases, the underlying molecular and cellular mechanisms that result in these debilitating anomalies remain largely unknown. Perturbed hedgehog (HH) signalling plays a major role in craniofacial development, and mutations in a number of pathway constituents underlie craniofacial...
Topics
- Animals
- Brain
- Cell Death
- Cell Proliferation
- Cell Shape
- Cleft Lip
- Cleft Palate
- Disease Models, Animal
- Epithelial Cells
- Fibroblast Growth Factors
- Genetic Association Studies
- Hedgehog Proteins
- Mesoderm