Article
Cardiac-specific suppression of NF-κB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
American journal of physiology. Heart and circulatory physiology - 1 Oct 2014
Thomas Candice M, Yong Qian Chen, Rosa Rodolfo M, Seqqat Rachid, Gopal Shanthi, Casarini Dulce E, Jones W Keith, Gupta Sudhiranjan, Baker Kenneth M, Kumar Rajesh
Abstract excerpt
Activation of NF-κB signaling in the heart may be protective or deleterious depending on the pathological context. In diabetes, the role of NF-κB in cardiac dysfunction has been investigated using pharmacological approaches that have a limitation of being nonspecific. Furthermore, the specific cellular pathways by which NF-κB modulates heart function in diabetes have not been identified. To address these...
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