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Article

Cardiac-specific blockade of NF-kappaB in cardiac pathophysiology: differences between acute and chronic stimuli in vivo.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2005

Brown Maria, McGuinness Michael, Wright Terry, Ren Xiaoping, Wang Yang, Boivin Gregory P, Hahn Harvey, Feldman Arthur M, Jones W Keith

Abstract excerpt

The role of NF-kappaB in cardiac physiology and pathophysiology has been difficult to delineate due to the inability to specifically block NF-kappaB signaling in the heart. Cardiac-specific transgenic models have recently been developed that repress NF-kappaB activation by preventing phosphorylation at specific serine residues of the inhibitory kappaB (IkappaB) protein isoform IkappaBalpha. However, these models...

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Identifiers

PMID: 15695559
DOI: 10.1152/ajpheart.00170.2004

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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