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Article

TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways.

Scientific reports - 13 Nov 2015

Li Lei, Chen Yi, Li Jing, Yin Haifeng, Guo Xiaoyun, Doan Jessica, Molkentin Jeffery D, Liu Qinghang

Abstract excerpt

TAK1 (TGFβ-activated kinase-1) signaling is essential in regulating a number of important biological functions, including innate immunity, inflammatory response, cell growth and differentiation, and myocardial homeostasis. The precise role of TAK1 in the adult heart under pathological conditions remains largely unknown. Importantly, we observed that TAK1 is upregulated during compensatory hypertrophy but...

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Identifiers

PMID: 26564789
DOI: 10.1038/srep16626
PMCID: PMC4643217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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