Article

I-κB kinase-ε deficiency attenuates the development of Doxorubicin-induced dilated cardiomyopathy

2022-06-10

Abstract excerpt

<title>Abstract</title> <p>Dilated cardiomyopathy (DCM) can lead to heart expansion and severe heart failure, but its specific pathogenesis is still elusive. In many cardiovascular diseases, I-κB kinase-ε (IKKε) has been recognized as a pro-inflammatory molecule. In this study, we aimed to determine the effect of IKKε on Dox-induced cardiomyopathy in mice. Wild-type mice (WT, n=14) and IKKε knockout mice (IKKε-KO...

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Literature Corpus work: d816a1b6-3e66-5dad-8027-b0e07c984e33
DOI: 10.21203/rs.3.rs-1683477/v1

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