Calcineurin A β Gene Targeting Predisposes the Myocardium to Acute Ischemia-Induced Apoptosis and Dysfunction

Abstract excerpt

Cardiovascular disease is the leading cause of mortality and morbidity within the industrialized nations of the world, with coronary heart disease (CHD) accounting for as much as 66% of these deaths. Acute myocardial infarction is a typical sequelae associated with long-standing coronary heart disease resulting in large scale loss of ventricular myocardium through both apoptotic and necrotic cell death. In this...

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