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<i>O</i> -GlcNAcylation, oxidation and CaMKII contribute to atrial fibrillation in type 1 and type 2 diabetes by distinct mechanisms

2020-02-19

Abstract excerpt

Diabetes mellitus and atrial fibrillation (AF) are major unsolved public health problems, and diabetes is an independent risk factor for AF in patients. However, the mechanism(s) underlying this clinical association is unknown. Elevated protein O -GlcNAcylation (OGN) and reactive oxygen species (ROS) are increased in diabetic hearts, and calmodulin kinase II (CaMKII) is a proarrhythmic signal that may be activate...

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Literature Corpus work
816bd0f3-9d47-5296-9a64-8d60a5eef117
DOI
10.1101/2020.02.18.954909
Open publication

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<i>O</i> -GlcNAcylation, oxidation and CaMKII contribute to atrial fibrillation in type 1 and type 2 diabetes by distinct mechanismsDOI 10.1101/2020.02.18.954909
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