Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.

Genome biology - 31 Jul 2014

Saraconi Giulia, Severi Francesco, Sala Cesare, Mattiuz Giorgio, Conticello Silvestro G

Abstract excerpt

BACKGROUND: The AID/APOBECs are deaminases that act on cytosines in a diverse set of pathways and some of them have been linked to the onset of genetic alterations in cancer. Among them, APOBEC1 is the only family member to physiologically target RNA, as the catalytic subunit in the Apolipoprotein B mRNA editing complex. APOBEC1 has been linked to cancer development in mice but its oncogenic mechanisms are not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APOBEC-1 Deaminase
Share to Benzamides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to Esophageal Neoplasms

Share to Imatinib Mesylate

Share to K562 Cells

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Piperazines

Source

Open in PubMed Open full text

Identifiers

PMID: 25085003
DOI: 10.1186/s13059-014-0417-z
PMCID: PMC4144122

Genes

APOBEC1
ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.PMID 25085003Read ↗

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.Semantic proximity Read ↗

APOBEC: From mutator to editor.Semantic proximity Read ↗

Aid and Apobec Deaminases: Balancing Dna Damage in Epigenetics and ImmunitySemantic proximity Read ↗

Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA.Semantic proximity Read ↗

Acute expression of human APOBEC3B in mice results in RNA editing and lethality.Semantic proximity Read ↗

Activation induced cytidine deaminase: An old friend with new facesSemantic proximity Read ↗

Evolution of the AID/APOBEC Family of Polynucleotide (Deoxy)cytidine DeaminasesSemantic proximity Read ↗

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.Semantic proximity Read ↗

Overexpression of ADAR1 in mice does not initiate or accelerate cancer formation <i>in vivo</i>Semantic proximity Read ↗

The AID/APOBEC family of nucleic acid mutatorsSemantic proximity Read ↗

AID and APOBECs as Multifaceted Intrinsic Virus-Restricting Factors: Emerging Concepts in the Light of COVID-19Semantic proximity Read ↗

AID/APOBEC cytosine deaminase induces genome-wide kataegis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.