Article
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.
Molecular cell - 1 Nov 2002
Harris Reuben S, Petersen-Mahrt Svend K, Neuberger Michael S
Abstract excerpt
APOBEC1 is the catalytic component of an RNA editing complex but shows homology to activation-induced cytidine deaminase (AID), a protein whose function is to potentiate diversification of immunoglobulin gene DNA. Here, we show that APOBEC1 and its homologs APOBEC3C and APOBEC3G exhibit potent DNA mutator activity in an E. coli assay. Indeed, like AID, these proteins appear to trigger DNA mutation through dC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.