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Aid and Apobec Deaminases: Balancing Dna Damage in Epigenetics and Immunity

1 Aug 2014

Abstract excerpt

DNA mutations and genomic recombinations are the origin of oncogenesis, yet parts of developmental programs as well as immunity are intimately linked to, or even depend on, such DNA damages. Therefore, the balance between deleterious DNA damages and organismal survival utilizing DNA editing (modification and repair) is in continuous flux. The cytosine deaminases AID/APOBEC are a DNA editing family and actively...

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PMID: 25333851
DOI: 10.2217/epi.14.35

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