Article

Overexpression of ADAR1 in mice does not initiate or accelerate cancer formation <i>in vivo</i>

2023-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Adenosine to inosine editing (A-to-I) in regions of double stranded RNA (dsRNA) is mediated by adenosine deaminase acting on RNA 1 (ADAR1) or ADAR2. ADAR1 and A-to-I editing levels are increased in many human cancers. It is not established if elevated ADAR1 represents a driver or passenger during cancer formation. We established a series of murine alleles to allow in vivo overexpression of ADAR...

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Literature Corpus work: 14c57313-d5cf-5d2c-af45-e86d1b0bf38f
DOI: 10.1101/2023.01.29.526130

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