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Activation induced cytidine deaminase: An old friend with new faces

27 Oct 2022

Abstract excerpt

Activation induced cytidine deaminase (AID) protein is a member of APOBEC family. AID converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class switch recombination (CSR). AID also plays critical roles in B cell precursor stages, removing polyreactive B cells from immune repertoire. Since the main function of AID is inducing point mutations, dysregulation can lead to increased...

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PMID: 36405752
DOI: 10.3389/fimmu.2022.965312

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