Article
Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer.
Journal of cancer research and clinical oncology - 1 Jan 2015
Kim Jong Gwang, Chae Yee Soo, Lee Soo Jung, Kang Byung Woog, Park Jae Yong, Lee Eun-Jin, Jeon Hyo-Sung, Park Jun Seok, Choi Gyu Seog
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) located in the 3'-UTR of miRNA target genes could affect miRNA-mediated gene regulation, thereby contributing to the susceptibility or prognosis of cancer. Accordingly, the present study analyzed SNPs located at putative miRNA-binding sites of the 3'-UTR of various genes and investigated their impact on the prognosis for patients with colorectal cancer. MATERIALS...
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