Article
Variation within 3'-UTRs of base excision repair genes and response to therapy in colorectal cancer patients: A potential modulation of microRNAs binding.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2013
Pardini Barbara, Rosa Fabio, Barone Elisa, Di Gaetano Cornelia, Slyskova Jana, Novotny Jan, Levy Miroslav, Garritano Sonia, Vodickova Ludmila, Buchler Tomas, Gemignani Federica, Landi Stefano, Vodicka Pavel, Naccarati Alessio
Abstract excerpt
PURPOSE: Colorectal cancer is routinely treated with a 5-fluorouracil (5-FU)-based chemotherapy. 5-FU incorporates into DNA, and the base excision repair (BER) pathway specifically recognizes such damage. We investigated the association of single-nucleotide polymorphisms (SNP) in the 3'-untranslated regions (UTR) of BER genes, and potentially affecting the microRNA (miRNA) binding, on the risk of colorectal...
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