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MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis.

Mutagenesis - 17 Oct 2017

Schneiderova Michaela, Naccarati Alessio, Pardini Barbara, Rosa Fabio, Gaetano Cornelia Di, Jiraskova Katerina, Opattova Alena, Levy Miroslav, Veskrna Karel, Veskrnova Veronika, Buchler Tomas, Landi Stefano, Vodicka Pavel, Vymetalkova Veronika

Abstract excerpt

According to the Vogelstein's model of colorectal carcinogenesis, genetic variations in highly penetrant genes may be involved in the colorectal cancer (CRC) pathogenesis. Similarly, aberrant function and/or altered expression of microRNAs (miRNAs) often occur in CRC. In this context, polymorphisms in miRNA-binding sites (miRSNPs) may affect miRNA/target gene interaction, resulting in differential mRNA/protein...

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PMID: 29048575
DOI: 10.1093/mutage/gex026

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PARP1
KRAS
APC
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SMAD7

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