Article
Identification of a functional polymorphism affecting microRNA binding in the susceptibility locus 1q25.3 for colorectal cancer.
Molecular carcinogenesis - 1 Sept 2017
Ke Juntao, Tian Jianbo, Li Jiaoyuan, Gong Yajie, Yang Yang, Zhu Ying, Zhang Yi, Zhong Rong, Chang Jiang, Gong Jing
Abstract excerpt
Genome-wide association studies (GWASs) have identified dozens of susceptibility loci for colorectal cancer (CRC). However, most of them lack functional genetic variants and clear biological mechanisms. MicroRNAs (miRNAs) are small noncoding RNAs involved in a variety of physiological and tumorigenic processes. Here we hypothesized that single nucleotide polymorphisms (SNPs) that affect miRNAs biogenesis and...
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