Article
A catalog of polymorphisms falling in microRNA-binding regions of cancer genes.
DNA and cell biology - 1 Jan 2008
Landi Debora, Gemignani Federica, Barale Roberto, Landi Stefano
Abstract excerpt
Recent evidence indicates that small, nonprotein-coding RNA molecules, called microRNAs (miRNAs), control cell growth, differentiation, and apoptosis, and are also involved in tumorigenesis. miRNAs can bind to the 3' untranslated regions (3'UTRs) of messenger RNAs and interfere with their translation. We hypothesized that common polymorphisms within their genes or within their targets could have an important...
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