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Article

Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2012

Xing Jinliang, Wan Shaogui, Zhou Feng, Qu Falin, Li Bingshan, Myers Ronald E, Fu Xiaoying, Palazzo Juan P, He Xianli, Chen Zhinan, Yang Hushan

Abstract excerpt

BACKGROUND: Cumulative data have shown that microRNAs (miRNA) are involved in the etiology and prognosis of colorectal cancer (CRC). Genetic polymorphisms in pre-miRNA genes may influence the biogenesis and functions of their host miRNAs. However, whether these polymorphisms are associated with CRC prognosis remains unknown. METHODS: We analyzed the effects of seven single-nucleotide polymorphisms (SNP) in...

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PMID: 22028396
DOI: 10.1158/1055-9965.EPI-11-0624
PMCID: PMC3253954

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