Article
Polymorphisms in MicroRNA Binding Sites Predict Colorectal Cancer Survival.
International journal of medical sciences - 1 Jan 2017
Yang Ying-Pi, Ting Wen-Chien, Chen Lu-Min, Lu Te-Ling, Bao Bo-Ying
Abstract excerpt
Background: MicroRNAs (miRNAs) mediate negative regulation of target genes through base pairing, and aberrant miRNA expression has been described in cancers. We hypothesized that single nucleotide polymorphisms (SNPs) within miRNA target sites might influence clinical outcomes in patients with colorectal cancer. Methods: Sixteen common SNPs within miRNA target sites were identified, and the association between...
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