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Article

Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts.

British journal of cancer - 9 Sept 2014

Chiu M, Tardito S, Pillozzi S, Arcangeli A, Armento A, Uggeri J, Missale G, Bianchi M G, Barilli A, Dall'Asta V, Campanini N, Silini E M, Fuchs J, Armeanu-Ebinger S, Bussolati O

Abstract excerpt

BACKGROUND: A subset of human hepatocellular carcinomas (HCC) exhibit mutations of β-catenin gene CTNNB1 and overexpress Glutamine synthetase (GS). The CTNNB1-mutated HCC cell line HepG2 is sensitive to glutamine starvation induced in vitro with the antileukemic drug Crisantaspase and the GS inhibitor methionine-L-sulfoximine (MSO). METHODS: Immunodeficient mice with subcutaneous xenografts of the CTNNB1-mutated...

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Identifiers

PMID: 25072259
DOI: 10.1038/bjc.2014.425
PMCID: PMC4453854

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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