Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival.

Journal of cancer research and clinical oncology - 1 Nov 2021

Schmidt Andreas, Armento Angela, Bussolati Ovidio, Chiu Martina, Ellerkamp Verena, Scharpf Marcus O, Sander Philip, Schmid Evi, Warmann Steven W, Fuchs Jörg

Abstract excerpt

PURPOSE: Glutamine plays an important role in cell viability and growth of various tumors. For the fetal subtype of hepatoblastoma, growth inhibition through glutamine depletion was shown. We studied glutamine depletion in embryonal cell lines of hepatoblastoma carrying different mutations. Since asparagine synthetase was identified as a prognostic factor and potential therapeutic target in adult hepatocellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Gene Expression

Share to Glutamate-Ammonia Ligase

Share to Glutamine

Share to Hepatoblastoma

Share to Liver Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 34235580
DOI: 10.1007/s00432-021-03713-4
PMCID: PMC8484192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival.PMID 34235580Read ↗

Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cellsSemantic proximity Read ↗

Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.Semantic proximity Read ↗

SLC1A3 contributes to L‐asparaginase resistance in solid tumorsSemantic proximity Read ↗

A clinically attainable dose of L‐asparaginase targets glutamine addiction in lymphoid cell linesSemantic proximity Read ↗

Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.Semantic proximity Read ↗

Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase.Semantic proximity Read ↗

Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastomaSemantic proximity Read ↗

MiR-513c suppresses neuroblastoma cell migration, invasion, and proliferation through direct targeting glutaminase (GLS)Semantic proximity Read ↗

Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer.Semantic proximity Read ↗

NAD+ biosynthesis as a collateral lethality target for precision oncologySemantic proximity Read ↗

Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts.Semantic proximity Read ↗

Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.