Article

One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression

2023-05-15

Abstract excerpt

Tumor cells generally require large amounts of nucleotides, and thus activate de novo purine synthesis ( dn PS). In the dn PS reactions, 10-formyltetrahydorofolate (10-fTHF) supplied by one-carbon metabolism is utilized as a formyl group donor. We focused on aldehyde dehydrogenase 1 family member L1 (ALDH1L1), which metabolizes 10-fTHF to tetrahydrofolate (THF) and whose expression is often attenuated in hepatocel...

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Literature Corpus work: 4d81551e-4819-5188-8e8b-e7eb9cd444f3
DOI: 10.21203/rs.3.rs-2823144/v1

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One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppressionDOI 10.21203/rs.3.rs-2823144/v1Read

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