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HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer

7 Aug 2020

Abstract excerpt

Methionine restriction, a dietary regimen that protects against metabolic diseases and aging, represses cancer growth and improves cancer therapy. However, the response of different cancer cells to this nutritional manipulation is highly variable, and the molecular determinants of this heterogeneity remain poorly understood. Here we report that hepatocyte nuclear factor 4α (HNF4α) dictates the sensitivity of...

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PMID: 32770044
DOI: 10.1038/s41467-020-17818-w

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