Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.

doi:10.1038/ncomms11971

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.

Nature communications - 20 Jun 2016

Hao Yujun, Samuels Yardena, Li Qingling, Krokowski Dawid, Guan Bo-Jhih, Wang Chao, Jin Zhicheng, Dong Bohan, Cao Bo, Feng Xiujing, Xiang Min, Xu Claire, Fink Stephen, Meropol Neal J, Xu Yan, Conlon Ronald A, Markowitz Sanford, Kinzler Kenneth W, Velculescu Victor E, Brunengraber Henri, Willis Joseph E, LaFramboise Thomas, Hatzoglou Maria, Zhang Guo-Fang, Vogelstein Bert, Wang Zhenghe

Abstract excerpt

Cancer cells often require glutamine for growth, thereby distinguishing them from most normal cells. Here we show that PIK3CA mutations reprogram glutamine metabolism by upregulating glutamate pyruvate transaminase 2 (GPT2) in colorectal cancer (CRC) cells, making them more dependent on glutamine. Compared with isogenic wild-type (WT) cells, PIK3CA mutant CRCs convert substantially more glutamine to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Citric Acid Cycle

Share to HCT116 Cells

Share to HT29 Cells

Share to Ketoglutaric Acids

Share to Pyruvate Dehydrogenase Acetyl-Transferring Kinase

Share to Transaminases

Share to Tumor Burden

Source

Open in PubMed Open full text

Identifiers

PMID: 27321283
DOI: 10.1038/ncomms11971
PMCID: PMC4915131

Genes

GPT2
ATF4
PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.PMID 27321283Read ↗

Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo.Semantic proximity Read ↗

Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis.Semantic proximity Read ↗

Dual targeting of glutamine metabolism and lysosomal function in eliminating drug-tolerant KRAS-mutant cancer cells.Semantic proximity Read ↗

FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer.Semantic proximity Read ↗

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.Semantic proximity Read ↗

Hypoxia and aspirin additively increase intracellular glutamine accumulation in PIK3CA-mutated colorectal cancer cells.Semantic proximity Read ↗

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers.Semantic proximity Read ↗

Glutamine deprivation counteracts hypoxia-induced chemoresistanceSemantic proximity Read ↗

Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells.Semantic proximity Read ↗

Targeting Altered Energy Metabolism in Colorectal Cancer: Oncogenic Reprogramming, the Central Role of the TCA Cycle and Therapeutic OpportunitiesSemantic proximity Read ↗

A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.Semantic proximity Read ↗

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.