Article
Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase.
Neoplasia (New York, N.Y.) - 1 Nov 2016
Toda Kosuke, Kawada Kenji, Iwamoto Masayoshi, Inamoto Susumu, Sasazuki Takehiko, Shirasawa Senji, Hasegawa Suguru, Sakai Yoshiharu
Abstract excerpt
A number of clinical trials have shown that KRAS mutations of colorectal cancer (CRC) can predict a lack of responses to anti-epidermal growth factor receptor-based therapy. Recently, there have been several studies to elucidate metabolism reprogramming in cancer. However, it remains to be investigated how mutated KRAS can coordinate the metabolic shift to sustain CRC tumor growth. In this study, we found that...
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