Article

Inhibiting Glutamine Metabolism Blocks Coronavirus Replication in Mammalian Cells

2023-09-28

Abstract excerpt

Developing therapeutic strategies against COVID-19 has gained widespread interest given the likelihood that new viral variants will continue to emerge. Here we describe one potential therapeutic strategy which involves targeting members of the glutaminase family of mitochondrial metabolic enzymes (GLS and GLS2), which catalyze the first step in glutamine metabolism, the hydrolysis of glutamine to glutamate. We sho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0a814ae6-fce9-55cf-9782-1866600df1c3
DOI: 10.1101/2023.09.27.559756

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibiting Glutamine Metabolism Blocks Coronavirus Replication in Mammalian CellsDOI 10.1101/2023.09.27.559756Read

A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.Semantic proximity Read

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.Semantic proximity Read

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2Semantic proximity Read

Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations.Semantic proximity Read

SARS-CoV-2 Infection Impacts Carbon Metabolism and Depends on Glutamine for Replication in Syrian Hamster AstrocytesSemantic proximity Read

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cellsSemantic proximity Read

Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review)Semantic proximity Read

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.Semantic proximity Read

Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.Semantic proximity Read

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic CancerSemantic proximity Read

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.Semantic proximity Read

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibitionSemantic proximity Read