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Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells

1 Nov 2002

Abstract excerpt

Human hepatoma cells take up glutamine at rates severalfold faster than the system N-mediated transport rates observed in normal human hepatocytes. Amino acid inhibition, kinetic, Northern blotting, RT-PCR, and restriction enzyme analyses collectively identified the transporter responsible in six human hepatoma cell lines as amino acid transporter B(0) (ATB(0)), the human ortholog of rodent ASCT2. The majority of...

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PMID: 12381519
DOI: 10.1152/ajpgi.00031.2002

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