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Article

Glutamine deprivation counteracts hypoxia-induced chemoresistance

22 Nov 2019

Abstract excerpt

The microenvironment of solid tumors is a key determinant of therapy efficacy. The co-occurrence of oxygen and nutrient deprivation is a common phenomenon of the tumor microenvironment and associated with treatment resistance. Cholangiocarcinoma (CCA) is characterized by a very poor prognosis and pronounced chemoresistance. A better understanding of the underlying molecular mechanisms is urgently needed to...

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PMID: 31765939
DOI: 10.1016/j.neo.2019.10.004

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