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Article

Hypoxia and aspirin additively increase intracellular glutamine accumulation in PIK3CA-mutated colorectal cancer cells.

Scientific reports - 24 Mar 2026

Umezaki Nodoka, Boku Shogen, Matsuo Yoshiyuki, Yamamoto Tetsushi, Satake Hironaga, Watanabe Motoki, Hirota Kiichi, Sugie Tomoharu, Sekimoto Mitsugu

Abstract excerpt

Aspirin exhibits potential as a repurposed agent for preventing and treating cancer, specifically PIK3CA-mutated (MT) colorectal cancer. However, the fundamental biological reasons for the particular antitumor activity of aspirin against PIK3CA-MT colorectal cancer are not yet fully elucidated. We have previously established that aspirin relates to glutamine metabolism in PIK3CA-MT colorectal cancer. In...

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Identifiers

PMID: 41876618
DOI: 10.1038/s41598-026-42753-z
PMCID: PMC13013922

Genes

PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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