Article

Supraphysiological glutamine as a means of depleting intracellular amino acids to enhance pancreatic cancer chemosensitivity

2023-11-30

Abstract excerpt

<title>Abstract</title> <p>Limited efficacy of systemic therapy for pancreatic ductal adenocarcinoma (PDAC) patients contributes to high mortality. Cancer cells develop strategies to secure nutrients in nutrient-deprived conditions and chemotherapy treatment. Despite the dependency of PDAC on glutamine (Gln) for growth and survival, strategies designed to suppress Gln metabolism have limited effects. Here, we dem...

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Literature Corpus work: 8411ef65-9162-53dd-a98a-76d5543bdec4
DOI: 10.21203/rs.3.rs-3647514/v1

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