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Article

Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Oct 2014

Cole Toby B, Li Wan-Fen, Co Aila L, Hay Ariel M, MacDonald James W, Bammler Theo K, Farin Federico M, Costa Lucio G, Furlong Clement E

Abstract excerpt

Chlorpyrifos oxon (CPO), the toxic metabolite of the organophosphorus (OP) insecticide chlorpyrifos, causes developmental neurotoxicity in humans and rodents. CPO is hydrolyzed by paraoxonase-1 (PON1), with protection determined by PON1 levels and the human Q192R polymorphism. To examine how the Q192R polymorphism influences fetal toxicity associated with gestational CPO exposure, we measured enzyme inhibition...

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Identifiers

PMID: 25070982
DOI: 10.1093/toxsci/kfu144
PMCID: PMC4271046

Genes

PON1
CPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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