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Article

The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status.

Advances in experimental medicine and biology - 1 Jan 2010

Cole Toby B, Jansen Karen, Park Sarah, Li Wan-Fen, Furlong Clement E, Costa Lucio G

Abstract excerpt

Most chemical exposures involve complex mixtures. The role of paraoxonase 1 (PON1) and the Q192R polymorphism in the detoxication of individual organophosphorous (OP) compounds has been well-established. The extent to which PON1 protects against a given OP is determined by its catalytic efficiency. We used a humanized transgenic mouse model of the Q192R polymorphism to demonstrate that PON1 modulates the toxicity...

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Source

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Identifiers

PMID: 20221870
DOI: 10.1007/978-1-60761-350-3_6
PMCID: PMC3035621

Genes

PON1
CPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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