Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds.

Toxicology and applied pharmacology - 15 Apr 2009

Jansen Karen L, Cole Toby B, Park Sarah S, Furlong Clement E, Costa Lucio G

Abstract excerpt

A transgenic mouse model of the human hPON1(Q192R) polymorphism was used to address the role of paraoxonase (PON1) in modulating toxicity associated with exposure to mixtures of organophosphorus (OP) compounds. Chlorpyrifos oxon (CPO), diazoxon (DZO), and paraoxon (PO) are potent inhibitors of carboxylesterases (CaE). We hypothesized that a prior exposure to these OPs would increase sensitivity to malaoxon (MO),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice, Transgenic
Share to Aryldialkylphosphatase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carboxylic Ester Hydrolases

Share to Dose-Response Relationship, Drug

Share to Environmental Pollutants

Share to Mice, Knockout

Share to Organophosphorus Compounds

Share to Pesticides

Source

Open in PubMed Open full text

Identifiers

PMID: 19371602
DOI: 10.1016/j.taap.2009.02.001
PMCID: PMC2717945

Genes

CPO
PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds.PMID 19371602Read ↗

The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status.Semantic proximity Read ↗

Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues.Semantic proximity Read ↗

Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression.Semantic proximity Read ↗

Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity.Semantic proximity Read ↗

Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants.Semantic proximity Read ↗

The PON1 gene and detoxication.Semantic proximity Read ↗

Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism.Semantic proximity Read ↗

Paraoxonase 1 status as a risk factor for disease or exposure.Semantic proximity Read ↗

Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds.Semantic proximity Read ↗

Effect of organophosphate intoxication on human serum paraoxonase.Semantic proximity Read ↗

Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity.Semantic proximity Read ↗

Characterization of human paraoxonase 1 variants suggest that His residues at 115 and 134 positions are not always needed for the lactonase/arylesterase activities of the enzyme.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.