Article
Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants.
Neurotoxicology - 1 Aug 2005
Furlong Clement E, Cole Toby B, Jarvik Gail P, Pettan-Brewer Christina, Geiss Gary K, Richter Rebecca J, Shih Diana M, Tward Aaron D, Lusis Aldons J, Costa Lucio G
Abstract excerpt
Individual differences in detoxication capacities for specific organophosphorous (OP) compounds are due largely to differences in catalytic efficiency or abundance of the HDL-associated enzyme, paraoxonase (PON1). First, we provide evidence that children less than 2 years of age represent a particularly susceptible population for OP exposure due to low abundance of PON1 and variable onset of plasma PON1 activity....
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