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Article

Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2011

Cole Toby B, Beyer Richard P, Bammler Theo K, Park Sarah S, Farin Federico M, Costa Lucio G, Furlong Clement E

Abstract excerpt

Microarray analysis was used to examine effects of repeated postnatal exposure to chlorpyrifos oxon (CPO) on gene expression in the cerebellum of genetically modified mice. The high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) plays a significant role in the detoxication of CPO, which is present in exposures and generated from chlorpyrifos (CPF) in vivo following exposure. Two factors are important...

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Source

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Identifiers

PMID: 21673326
DOI: 10.1093/toxsci/kfr157
PMCID: PMC3164442

Genes

PON1
CPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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