Article
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.
Human molecular genetics - 20 Dec 2014
Okada Yukinori, Kim Kwangwoo, Han Buhm, Pillai Nisha E, Ong Rick T-H, Saw Woei-Yuh, Luo Ma, Jiang Lei, Yin Jian, Bang So-Young, Lee Hye-Soon, Brown Matthew A, Bae Sang-Cheol, Xu Huji, Teo Yik-Ying, de Bakker Paul I W, Raychaudhuri Soumya
Abstract excerpt
Previous studies have emphasized ethnically heterogeneous human leukocyte antigen (HLA) classical allele associations to rheumatoid arthritis (RA) risk. We fine-mapped RA risk alleles within the major histocompatibility complex (MHC) in 2782 seropositive RA cases and 4315 controls of Asian descent. We applied imputation to determine genotypes for eight class I and II HLA genes to Asian populations for the first...
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