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Article

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.

Nature genetics - 29 Jan 2012

Raychaudhuri Soumya, Sandor Cynthia, Stahl Eli A, Freudenberg Jan, Lee Hye-Soon, Jia Xiaoming, Alfredsson Lars, Padyukov Leonid, Klareskog Lars, Worthington Jane, Siminovitch Katherine A, Bae Sang-Cheol, Plenge Robert M, Gregersen Peter K, de Bakker Paul I W

Abstract excerpt

The genetic association of the major histocompatibility complex (MHC) to rheumatoid arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate persists about the identity of the causal variants in HLA-DRB1 and the presence of independent effects elsewhere in the MHC. Using existing genome-wide SNP data in 5,018 individuals with seropositive rheumatoid arthritis (cases) and 14,974...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to HLA-B Antigens

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Source

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Identifiers

PMID: 22286218
DOI: 10.1038/ng.1076
PMCID: PMC3288335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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