Article
Generating thermostabilized agonist-bound GPR40/FFAR1 using virus-like particles and a label-free binding assay.
Molecular membrane biology - 1 Aug 2014
Hirozane Yoshihiko, Motoyaji Takashi, Maru Takamitsu, Okada Kengo, Tarui Naoki
Abstract excerpt
Elucidating the detailed mechanism of activation of membrane protein receptors and their ligand binding is essential for structure-based drug design. Membrane protein crystal structure analysis successfully aids in understanding these fundamental molecular interactions. However, protein crystal structure analysis of the G-protein-coupled receptor (GPCR) remains challenging, even for the class of GPCRs which have...
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