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Article

Probing thermostability of detergent-solubilized CB2 receptor by parallel G protein-activation and ligand-binding assays.

The Journal of biological chemistry - 3 Jan 2020

Beckner Ryan L, Zoubak Lioudmila, Hines Kirk G, Gawrisch Klaus, Yeliseev Alexei A

Abstract excerpt

G protein-coupled receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of a broad spectrum of physiological processes and are a major target for pharmaceutical drug development. Structural studies can help advance the rational design of novel specific pharmaceuticals that target GPCRs, but such studies require expression of significant quantities of these proteins in...

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Identifiers

PMID: 31776188
DOI: 10.1074/jbc.RA119.010696
PMCID: PMC6952600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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