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Article

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2012

Hudson Brian D, Christiansen Elisabeth, Tikhonova Irina G, Grundmann Manuel, Kostenis Evi, Adams David R, Ulven Trond, Milligan Graeme

Abstract excerpt

When it is difficult to develop selective ligands within a family of related G-protein-coupled receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (RASSLs) are useful alternatives for probing receptor function. In the present work, we explored whether a RASSL of the free fatty acid receptor 2 (FFA2) could be developed on the basis of pharmacological variation between species...

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Identifiers

PMID: 22919070
DOI: 10.1096/fj.12-213314
PMCID: PMC3509056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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