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Article

Free fatty acid receptors: structural models and elucidation of ligand binding interactions.

BMC structural biology - 7 Sept 2015

Tikhonova Irina G, Poerio Elena

Abstract excerpt

BACKGROUND: The free fatty acid receptors (FFAs), including FFA1 (orphan name: GPR40), FFA2 (GPR43) and FFA3 (GPR41) are G protein-coupled receptors (GPCRs) involved in energy and metabolic homeostasis. Understanding the structural basis of ligand binding at FFAs is an essential step toward designing potent and selective small molecule modulators. RESULTS: We analyse earlier homology models of FFAs in light of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, G-Protein-Coupled

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Identifiers

PMID: 26346819
DOI: 10.1186/s12900-015-0044-2
PMCID: PMC4561419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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