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Article

How Can Mutations Thermostabilize G-Protein-Coupled Receptors?

Trends in pharmacological sciences - 1 Jan 2016

Vaidehi Nagarajan, Grisshammer Reinhard, Tate Christopher G

Abstract excerpt

Structures of over 30 different G-protein-coupled receptors (GPCRs) have advanced our understanding of cell signaling and have provided a foundation for structure-guided drug design. This exciting progress has required the development of three complementary methods to facilitate GPCR crystallization, one of which is the thermostabilization of receptors by systematic mutagenesis. However, the reason why a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26547284
DOI: 10.1016/j.tips.2015.09.005
PMCID: PMC4698185

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