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Article

Engineering the elongation factor Tu for efficient selenoprotein synthesis.

Nucleic acids research - 1 Sept 2014

Haruna Ken-ichi, Alkazemi Muhammad H, Liu Yuchen, Söll Dieter, Englert Markus

Abstract excerpt

Selenocysteine (Sec) is naturally co-translationally incorporated into proteins by recoding the UGA opal codon with a specialized elongation factor (SelB in bacteria) and an RNA structural signal (SECIS element). We have recently developed a SECIS-free selenoprotein synthesis system that site-specifically--using the UAG amber codon--inserts Sec depending on the elongation factor Tu (EF-Tu). Here, we describe the...

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Identifiers

PMID: 25064855
DOI: 10.1093/nar/gku691
PMCID: PMC4150793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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