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Article

Recoding of the selenocysteine UGA codon by cysteine in the presence of a non-canonical tRNACys and elongation factor SelB.

RNA biology - 1 Jan 2018

Vargas-Rodriguez Oscar, Englert Markus, Merkuryev Anna, Mukai Takahito, Söll Dieter

Abstract excerpt

In many organisms, the UGA stop codon is recoded to insert selenocysteine (Sec) into proteins. Sec incorporation in bacteria is directed by an mRNA element, known as the Sec-insertion sequence (SECIS), located downstream of the Sec codon. Unlike other aminoacyl-tRNAs, Sec-tRNASec is delivered to the ribosome by a dedicated elongation factor, SelB. We recently identified a series of tRNASec-like tRNA genes...

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Identifiers

PMID: 29879865
DOI: 10.1080/15476286.2018.1474074
PMCID: PMC6103700

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Source receipt: pubmed, retrieved 7 Sept 2026.

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