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Article

Engineered rRNA enhances the efficiency of selenocysteine incorporation during translation.

Journal of the American Chemical Society - 9 Jan 2013

Thyer Ross, Filipovska Aleksandra, Rackham Oliver

Abstract excerpt

We developed a new genetic selection approach to screen for mutations that can alter the efficiency of selenocysteine incorporation. We identified mutations in 16S rRNA that increase or decrease the efficiency of selenocysteine incorporation in Escherichia coli without influencing the efficiency or fidelity of canonical translation. Engineered ribosomes with improved selenocysteine incorporation provide...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23256865
DOI: 10.1021/ja3069177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Engineered rRNA enhances the efficiency of selenocysteine incorporation during translation.PMID 23256865Read ↗

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