Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel structural determinants in human SECIS elements modulate the translational recoding of UGA as selenocysteine

3 Aug 2009

Abstract excerpt

The selenocysteine insertion sequence (SECIS) element directs the translational recoding of UGA as selenocysteine. In eukaryotes, the SECIS is located downstream of the UGA codon in the 3'-UTR of the selenoprotein mRNA. Despite poor sequence conservation, all SECIS elements form a similar stem-loop structure containing a putative kink-turn motif. We functionally characterized the 26 SECIS elements encoded in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Digestive system and related health
Share to Selenium in Biological Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19651878
DOI: 10.1093/nar/gkp635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel structural determinants in human SECIS elements modulate the translational recoding of UGA as selenocysteinePMID 19651878Read ↗

Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2.Semantic proximity Read ↗

A novel protein domain induces high affinity selenocysteine insertion sequence binding and elongation factor recruitment.Semantic proximity Read ↗

Functionality of mutations at conserved nucleotides in eukaryotic SECIS elements is determined by the identity of a single nonconserved nucleotide.Semantic proximity Read ↗

Efficient incorporation of multiple selenocysteines involves an inefficient decoding step serving as a potential translational checkpoint and ribosome bottleneck.Semantic proximity Read ↗

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.Semantic proximity Read ↗

Engineering the elongation factor Tu for efficient selenoprotein synthesis.Semantic proximity Read ↗

3S-DB Identifies an RNA Repository Facilitating Stop Codon Readthrough for Selenocysteine Insertion and Selenoproteome ExpansionSemantic proximity Read ↗

Characterization of Mammalian SelenoproteomesSemantic proximity Read ↗

Mechanism and regulation of selenoprotein synthesis.Semantic proximity Read ↗

Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2.Semantic proximity Read ↗

A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium.Semantic proximity Read ↗

Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.